Metformin's contraindications should be contraindicated.

Metformin's contraindications: needed for now.

Can contraindications compromise evidence-based, patient-centered clinical practice?

BACKGROUND Despite their often weak evidence base, contraindications convey the unequivocally adverse risk-benefit profile of an intervention in a specific clinical context. However, some patients in that context may nonetheless prefer the contraindicated intervention (with its potential benefits and risks) to the available alternatives. The impact of contraindications on treatment decisions re...

Extended utilization of noninvasive ventilation for acute respiratory failure and its clinical outcomes.

BACKGROUND Noninvasive ventilation (NIV) has increasingly been used for the treatment of acute respiratory failure. Despite recommendations supporting its utilization in a limited group of patients, NIV is frequently relied on as a first line treatment. We conducted a retrospective study to assess whether the extended use of NIV is associated with worse clinical outcomes. METHODS This was a r...

Use of Contraindicated Antiplatelet Medications in the Setting of Percutaneous Coronary Intervention: Insights From the Veterans Affairs Clinical Assessment, Reporting, and Tracking Program.

BACKGROUND Several antiplatelet medications used during and after percutaneous coronary intervention (PCI) are contraindicated for specific patient groups. A broad assessment of contraindicated medication use and associated clinical outcomes is not well described. METHODS AND RESULTS Using national Veterans Affairs Clinical Assessment, Reporting, and Tracking Program data for all PCI between ...

Apomorphine infusion in advanced Parkinson's patients with subthalamic stimulation contraindications.

BACKGROUND The efficacy of continuous subcutaneous apomorphine infusion (APO) has been evaluated in advanced Parkinson's disease in several open-label studies but never in a population of patients for whom subthalamic nucleus deep brain stimulation (STN-DBS) was contraindicated. METHODS The aim of this study was to evaluate the efficacy and cognitive safety of APO at 12-month follow-up in 23 ...